Email newsletters sign up1/4/2024 ![]() ![]() EVs may have a good, beneficial role in that," says Rathinam. Microbial products from microbiota in the gut are released into circulation, and are important for the body. "We think this has a role in normal physiology as well as in infections. Second, when they transferred these EVs with green LPS to another group of mice, they found green LPS inside the cells in the recipient mice, setting off inflammation.Īlthough they have not yet tried the experiments with microbial products other than LPS, they suspect a similar thing would happen. After about an hour, they found the green LPS on EVs in the mice's blood. First, they injected green-labeled LPS, a product made by bacteria, into mice. To show that EVs were actually transporting the bacterial pieces and bringing them into cells, Kumari, Rathinam and their colleagues did a series of experiments. "But we didn't know how microbial products reaching the blood from harmful or friendly bacteria go from outside the cell to inside the cell," Rathinam says. Or they can cause cells to explode themselves and cause inflammation, depending on the type of bacteria and the product involved. When the receptors inside of cells detect them, the signals from bacteria can help the gut, immune system and even brain function properly. The products can come from infectious bacteria invading, or they can come from friendly bacteria, for example, the ones that live in our intestines. "We understood which microbial products go into circulation," says Rathinam, an associate professor in the department of immunology. But they didn't know how those bacterial products actually got inside of our cells. Sign up to receive news and information from the Poetry Foundation: Poem of the Day, POETRY magazine, Events, and other newsletters. If you havent signed up to any of our email. Researchers knew that our cells have receptors inside of them that detect bacterial products. Sign up to receive regular email newsletters about consultations. "We found EVs patrol the circulation for systemic microbial products and alert an immune surveillance network inside the cell," says Kumari, a postdoctoral researcher in the Rathinam lab. The EV then brings the bacterial products along with its other contents inside of whichever human cell snags it. The walls of an EV can pick up pieces of bacteria, which usually have a lipid section that easily slips into the lipid walls of the EV. Now, University of Connecticut School of Medicine immunologists Puja Kumari, Vijay Rathinam, and colleagues report that EVs do something else, entirely unexpected. Inside the EVs are usually molecules that act as messages informing the receiving cell's behavior or growth. ![]() When another cell comes across an EV, it takes it inside itself and opens it up. Cells produce the EVs, tiny bubbles with a water-resistant shell made of fatty substances called lipids, and send them into the bloodstream. Extracellular vesicles (EVs) are like a postal service for our cells. ![]()
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